PRIMARY RESEARCH | PUBMED LINKS
DRUG CATEGORY: PEPTIDES+ (TISSUE RECOVERY)
DRUG NAME: PENTOSAN POLYSULFATE

  • FDA Safety Data Sheet not available

  • Smith MM. Pentosan Polysulfate, a Semisynthetic Heparinoid Disease-Modifying Osteoarthritic Drug with Roles in Intervertebral Disc Repair Biology Emulating the Stem Cell Instructive and Tissue Reparative Properties of Heparan Sulfate. Stem Cells Dev. 2022 [PubMed Link]

  • Siddiq MA. Efficacy and safety of pentosan polysulfate sodium in people with symptomatic knee osteoarthritis and dyslipidaemia: protocol of the MaRVeL trial. BMJ Open. 2024 [PubMed Link]

  • Siddiq MA. New therapeutic strategies in osteoarthritis. Joint Bone Spine. 2024 [PubMed Link]

  • Suranji Wijekoon HM. Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis. Res Vet Sci. 2019 [PubMed Link]

  • Smith M. Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues. Pharmaceuticals (Basel). 2023 [PubMed Link]

  • Herrero LJ. Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease. J Virol. 2015 [PubMed Link]

  • Krishnan R. Pentosan polysulfate sodium for Ross River virus-induced arthralgia: a phase 2a, randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2021 [PubMed Link]

  • Solanki P. Repurposing pentosan polysulfate sodium as hyaluronic acid linked polyion complex nanoparticles for the management of osteoarthritis: A potential approach. Med Hypotheses. 2021 [PubMed Link]

  • Kumagai K. Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis--an open clinical trial. BMC Clin Pharmacol. 2010 [PubMed Link]

  • Ghosh P. The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment. Semin Arthritis Rheum. 1999 [PubMed Link]

  • Stapledon CJ. Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis. PLoS One. 2019 [PubMed Link]

  • Ghosh P. Interactions of pentosan polysulfate with cartilage matrix proteins and synovial fibroblasts derived from patients with osteoarthritis. Osteoarthritis Cartilage. 1996 [PubMed Link]