TB-500 (Thymosin Beta-4)

PEPTIDES+ MEMBERS ONLY

INDICATIONS FOR USE

TB-500 is a synthetic peptide derived from thymosin beta-4, a naturally occurring protein found in almost all human cells. It is primarily used off-label to promote tissue repair, reduce inflammation, and improve recovery from musculoskeletal injuries, soft tissue damage, and surgical procedures. It is also investigated for its benefits in managing autoimmune diseases and hair loss.

ROUTE OF ADMINISTRATION

  • Subcutaneous or intramuscular injection. Systemic injections are typically used for broader therapeutic effects, while localized injections may be used in specific injury sites.

FORMULATIONS AND PRICING

FormulationPrice
15mg vial (3mg/mL x 5mL)$130
30mg vial (6mg/mL x 5mL)$250

COMMON INITIAL DOSING REGIMENS

  • The typical regimen involves 2–2.5 mg injected subcutaneously or intramuscularly twice weekly for 4–6 weeks, followed by a maintenance dose of 1 mg weekly or as needed.

MECHANISM OF ACTION

  • TB-500 regulates the actin cytoskeleton within cells, promoting cellular migration and differentiation. This mechanism enhances wound healing, tissue regeneration, and angiogenesis. It also reduces inflammation through modulation of pro-inflammatory cytokines and oxidative stress.

  • By promoting endothelial cell differentiation, TB-500 contributes to new blood vessel formation, accelerating the healing of injuries such as tendons, ligaments, and skin wounds. Its ability to upregulate keratinocyte and fibroblast activity further aids in wound healing and hair follicle regeneration.

COMMON SIDE EFFECTS

  • Localized Reactions: Mild pain or redness at the injection site, though rare.

  • Systemic Effects: Fatigue, headache, or dizziness have been reported but are infrequent.

  • Immune Response: Some users experience flu-like symptoms initially, possibly due to immune system activation.

  • Rare Effects: Allergic reactions such as rashes or swelling are uncommon. There are no confirmed reports of significant toxicity with TB-500, but long-term safety data is limited.

CONTRAINDICATIONS

  • Absolute: Hypersensitivity to BPC-157 or excipients.

  • Relative: Patients with autoimmune diseases should use BPC-157 cautiously, as immune modulation by peptides could theoretically exacerbate certain conditions. It should also be avoided in pregnant or breastfeeding individuals due to insufficient safety data.

COMPARISON WITH BPC-157

  • TB-500 and BPC-157 are complementary in their healing mechanisms but differ significantly in their scope of effects. TB-500 specializes in systemic repair by enhancing cellular migration and reducing inflammation, making it ideal for larger injuries or diffuse tissue damage. In contrast, BPC-157 excels in localized healing and gastrointestinal protection.

  • TB-500 acts more prominently on actin regulation and cellular repair, while BPC-157 focuses on collagen synthesis and angiogenesis. TB-500’s systemic effects may make it more suitable for athletes or patients recovering from extensive injuries, whereas BPC-157 is preferred for targeted treatments or conditions like ulcers and inflammatory bowel disease.

MORE INFORMATION

  • FDA Safety Data Sheet not available (experimental peptide therapy)

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  • Sosne G. Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis. Int Immunopharmacol. 2023 [PubMed Link]

  • Bako P. Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals. Int Immunopharmacol. 2023 [PubMed Link]

  • Bock-Marquette. Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies. Int Immunopharmacol. 2023 [PubMed Link]

  • Xing Y. Progress on the Function and Application of Thymosin β4. Front Endocrinol (Lausanne). 2021 [PubMed Link]

  • Gonzalez-Franquesa A. Discovery of thymosin β4 as a human exerkine and growth factor. Am J Physiol Cell Physiol. 2021 [PubMed Link]

  • Wang X. A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers. J Cell Mol Med. 2021 [PubMed Link]

  • Tian Z. Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation. Inflammation. 2022 [PubMed Link]

  • Yu R. Recombinant human thymosin beta-4 (rhTβ4) improved scalp condition and microbiome homeostasis in seborrheic dermatitis. Microb Biotechnol. 2021 [PubMed Link]

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  • Lv S. Thymosin‑β 4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF‑κB pathway. Int J Mol Med. 2020 [PubMed Link]

  • Song K. Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction. Eur J Pharmacol. 2020 [PubMed Link]

  • Pipes GT. Cardioprotection by Thymosin Beta 4. Vitam Horm. 2016 [PubMed Link]

  • Ho JH. Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage. Br J Ophthalmol. 2008 [PubMed Link]