NAD+

PEPTIDES+ MEMBERS ONLY

INDICATIONS FOR USE

NAD+ supplementation is primarily investigated in anti-aging medicine, metabolic health, and neuroprotection. It is proposed to enhance cellular energy, reduce age-related fatigue, and improve cognitive and mitochondrial function. NAD+ has also been studied for its role in managing neurodegenerative diseases and metabolic syndromes.

ROUTE OF ADMINISTRATION

  • Oral, sublingual, subcutaneous, or intranasal.

COMMON INITIAL DOSING REGIMENS

  • Oral/Sublingual: 300–600 mg daily.

  • Subcutaneous: 100–300 mg administered up to 3 times per week.

  • Intranasal: Doses vary, often using specialized nasal sprays delivering 50–100 mg daily.

MECHANISM OF ACTION

  • NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in redox reactions, mitochondrial function, and cellular repair mechanisms. It acts as a substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs), regulating DNA repair, gene expression, and cellular stress responses. By boosting NAD+ levels, cellular metabolism, energy production, and resilience to oxidative damage are enhanced.

COMMON SIDE EFFECTS

  • Mild: Nausea, flushing, or lightheadedness, particularly with intravenous administration.

  • Metabolic: Fatigue or headache during initial use.

  • Injection or IV-related: Pain at the infusion site or localized swelling.

  • Rare: Hypersensitivity reactions, although infrequent, may include rash or mild anaphylaxis.

CONTRAINDICATIONS

  • Absolute: Hypersensitivity to NAD+ or its derivatives.

  • Relative: Use cautiously in patients with severe systemic illnesses, liver or kidney disease, or a history of allergic reactions to supplements.

DISCLAIMER

  • Although NAD+ is widely available as a supplement, subcutaneous administration is not FDA-approved for any specific indications.

MORE INFORMATION

  • FDA Safety Data Sheet not available.

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