INDICATIONS FOR USE

Dihexa is an investigational peptide studied for its potential in cognitive enhancement, neuroprotection, and the treatment of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. It is also explored for its ability to promote synaptogenesis and neuronal repair in traumatic brain injuries.

ROUTE OF ADMINISTRATION

• Oral capsules

COMMON INITIAL DOSING REGIMENS

• Oral: 2mg–20 mg daily.

MECHANISM OF ACTION

• Dihexa is an angiotensin IV analog that acts on the hepatocyte growth factor (HGF)/c-Met signaling pathway, which is critical for neuronal development and repair. It enhances synaptogenesis, promotes dendritic spine formation, and improves cognitive function. By potentiating HGF activity, Dihexa supports neuroplasticity and protects against neurodegeneration.

COMMON SIDE EFFECTS

• Mild: Headache, fatigue, or mild dizziness.

• Metabolic: Rare reports of gastrointestinal discomfort.

• Neurological: Potential overstimulation in sensitive individuals, leading to irritability or insomnia.

• Long-term safety data is limited, and effects on hormonal or systemic functions are not well understood.

CONTRAINDICATIONS

• Absolute: Known hypersensitivity to Dihexa or its excipients.

• Relative: Patients with active cancer should use caution, as the promotion of cellular growth via HGF/c-Met could theoretically exacerbate tumor proliferation. Limited data exists regarding its use during pregnancy or breastfeeding.

DISCLAIMER

• This peptide is experimental and not FDA-approved.

LEARN MORE

• Evidence hound? Review our comprehensive listing of PubMed direct links to original research related to this medication.