INDICATIONS FOR USE

Delta Sleep-Inducing Peptide (DSIP) is an experimental therapy primarily researched for its potential to improve sleep quality, promote deeper and more restorative sleep cycles, and regulate circadian rhythms. It has also been studied for its potential to reduce stress, enhance recovery, and alleviate certain types of chronic pain, such as those associated with fibromyalgia.

ROUTE OF ADMINISTRATION

• Subcutaneous injection

COMMON INITIAL DOSING REGIMENS

• Initial dosing commonly ranges from 100 to 300 micrograms injected subcutaneously, typically administered in the evening before sleep. Dosages may be adjusted based on individual response and tolerance, with some protocols suggesting daily use, while others recommend intermittent schedules (e.g., 3–5 times weekly).

MECHANISM OF ACTION

• DSIP is a neuropeptide that modulates the sleep-wake cycle by interacting with the central nervous system, particularly regions involved in circadian rhythm regulation. It is thought to promote sleep by enhancing slow-wave (delta) sleep, reducing arousal levels, and regulating levels of sleep-promoting hormones like melatonin. DSIP also modulates stress response pathways, including those mediated by corticotropin-releasing factor (CRF), which may contribute to its calming effects.

COMMON SIDE EFFECTS

• Mild and uncommon due to its limited systemic effects. Reported side effects include fatigue or lethargy upon waking if the dose is too high or administered at the wrong time, injection site reactions, such as redness or mild irritation, and headache or dizziness in rare cases.

CONTRAINDICATIONS

• Absolute: Hypersensitivity to DSIP or any of its components.'

• Relative: Caution is advised in individuals with severe psychiatric conditions, untreated sleep disorders (e.g., severe obstructive sleep apnea), or those on medications affecting the CNS. Long-term safety data is limited, so use in individuals with significant medical conditions or during pregnancy/lactation should be undertaken with caution.

LEARN MORE

• Evidence hound? Review our comprehensive listing of PubMed direct links to original research related to this medication.