INDICATIONS FOR USE

MOTS-C is an experimental peptide investigated for its role in mitochondrial function, energy regulation, and metabolic health. It shows promise for age-related metabolic disorders, obesity, and type 2 diabetes.

ROUTE OF ADMINISTRATION

• Subcutaneous injection.

COMMON INITIAL DOSING REGIMENS

• Research protocols often involve 10–20 mg administered subcutaneously 2–3 times per week for several weeks, followed by rest periods.

• Suggested protocol: Inject 5mg (50 units via insulin syringe) SQ every 5 days for 20 days; may repeat once every 6 months

MECHANISM OF ACTION

• MOTS-C is encoded by mitochondrial DNA and regulates metabolic homeostasis by modulating AMPK and insulin sensitivity. It enhances mitochondrial function, promotes glucose uptake, and protects against metabolic stress.

COMMON SIDE EFFECTS

• Mild: Fatigue, headache, or injection site reactions.

• Rare: Potential mitochondrial overactivation leading to oxidative stress or tissue fatigue.

CONTRAINDICATIONS

• Absolute: Hypersensitivity to MOTS-C or its excipients.

• Relative: Use cautiously in individuals with mitochondrial disorders, as overactivation may exacerbate underlying dysfunction.

LEARN MORE

• Evidence hound? Review our comprehensive listing of PubMed direct links to original research related to this medication.