INDICATIONS FOR USE

NAD+ supplementation is primarily investigated in anti-aging medicine, metabolic health, and neuroprotection. It is proposed to enhance cellular energy, reduce age-related fatigue, and improve cognitive and mitochondrial function. NAD+ has also been studied for its role in managing neurodegenerative diseases and metabolic syndromes.

ROUTE OF ADMINISTRATION

• Oral, sublingual, subcutaneous, or intranasal.

COMMON INITIAL DOSING REGIMENS

• Oral/Sublingual: 300–600 mg daily.

• Subcutaneous: 100–300 mg administered up to 3 times per week.

• Intranasal: Doses vary, often using specialized nasal sprays delivering 50–100 mg daily.

MECHANISM OF ACTION

• NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in redox reactions, mitochondrial function, and cellular repair mechanisms. It acts as a substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs), regulating DNA repair, gene expression, and cellular stress responses. By boosting NAD+ levels, cellular metabolism, energy production, and resilience to oxidative damage are enhanced.

COMMON SIDE EFFECTS

• Mild: Nausea, flushing, or lightheadedness, particularly with intravenous administration.

• Metabolic: Fatigue or headache during initial use.

• Injection or IV-related: Pain at the infusion site or localized swelling.

• Rare: Hypersensitivity reactions, although infrequent, may include rash or mild anaphylaxis.

CONTRAINDICATIONS

• Absolute: Hypersensitivity to NAD+ or its derivatives.

• Relative: Use cautiously in patients with severe systemic illnesses, liver or kidney disease, or a history of allergic reactions to supplements.

DISCLAIMER

• Although NAD+ is widely available as a supplement, subcutaneous administration is not FDA-approved for any specific indications.

LEARN MORE

• Evidence hound? Review our comprehensive listing of PubMed direct links to original research related to this medication.