INDICATIONS FOR USE

Semax is a synthetic peptide utilized for neuroprotection and cognitive enhancement. It is used off-label for improving focus, memory, and mood, as well as for reducing symptoms of depression or anxiety. It has also been studied for ischemic stroke recovery.

ROUTE OF ADMINISTRATION

• Intranasal spray.

COMMON INITIAL DOSING REGIMENS

• 250–1,000 mcg per dose intranasally, administered 1–3 times daily depending on the condition.

MECHANISM OF ACTION

• Semax is a synthetic analog of adrenocorticotropic hormone (ACTH) without hormonal activity. It upregulates brain-derived neurotrophic factor (BDNF) and other neurotrophic factors, enhancing neuroplasticity, cognitive resilience, and neuronal repair. Semax also modulates dopamine and serotonin systems, contributing to mood stabilization and focus.

COMMON SIDE EFFECTS

• Mild: Nasal irritation, headache, or mild dizziness.

• Neurological: Restlessness, irritability, or transient mood swings in some individuals.

• Rare: Fatigue or decreased appetite with frequent high dosing.

• Long-term safety is not fully established, particularly with prolonged use.

CONTRAINDICATIONS

• Absolute: Hypersensitivity to Semax or its components.

• Relative: Caution is advised in patients with mood disorders, as it may exacerbate symptoms of mania or severe anxiety. Limited data exists regarding its use in pregnancy or breastfeeding.

DISCLAIMER: Semax is not FDA-approved and is considered experimental outside its approved indications in Russia.

LEARN MORE

• Evidence hound? Review our comprehensive listing of PubMed direct links to original research related to this medication.