INDICATIONS FOR USE

Testosterone cypionate is used off-label in women to address hypoandrogenism, symptoms of menopause, and sexual dysfunction. It is also utilized for improving energy, mood, bone density, and muscle mass.

ROUTE OF ADMINISTRATION

• Intramuscular injection

• Subcutaneous injection

COMMON INITIAL DOSING REGIMENS

• For women, low doses such as 2–10 mg intramuscularly every 1–2 weeks are typically used. Dosing is carefully titrated based on clinical symptoms and serum testosterone levels.

MECHANISM OF ACTION

• Testosterone cypionate is a synthetic form of testosterone that binds to androgen receptors, influencing gene expression. It promotes anabolic effects like increased protein synthesis and reduced fat deposition while modulating libido and mood.

COMMON SIDE EFFECTS

• Endocrine: Potential virilizing effects, including voice deepening, acne, and increased body or facial hair.

• General: Mood changes, fluid retention, and fatigue may occur during dose adjustments.

• Reproductive: Menstrual irregularities or cessation of menstruation in premenopausal women.

• Rare: Long-term use may increase risks of polycythemia or cardiovascular issues.

CONTRAINDICATIONS

• Absolute: Pregnancy, breastfeeding, or known hypersensitivity to testosterone cypionate.

• Relative: Use with caution in women with a history of hormone-sensitive cancers, significant liver or kidney dysfunction, or untreated sleep apnea.

LEARN MORE

• Evidence hound? Review our comprehensive listing of PubMed direct links to original research related to this medication.